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12 Best Rom-Com Anime Like My Friend's Little Sister Has It In for Me!

My Friend's Little Sister Has It In for Me!

Dive into the hilarious world of My Friend's Little Sister Has It In for Me!, also known as Tomodachi no Imouto ga Ore ni dake Uzai. This engaging Comedy, Romance, and School anime series follows high schooler Akiteru Oboshi, who believes youthful experiences are a waste of time. His life takes an annoying turn with Iroha Kohinata, his best friend's sister, who constantly teases him and seems to live in his room. Experience their unique school life dynamic as Akiteru grapples with Iroha's clingy antics. Fans of slice of life and romantic comedy will enjoy this charming anime about unexpected connections and the chaos of youth.

Explore a fantastic selection of anime like My Friend's Little Sister Has It In for Me!, filled with heartwarming romance, comedic misunderstandings, and relatable characters that will keep you entertained.

A Romantic Comedy Where the Childhood Friend Absolutely Will Not Lose

A Romantic Comedy Where the Childhood Friend Absolutely Will Not Lose - Kuroha's revenge plot to win Maru Sueharu's heart.
A Romantic Comedy Where the Childhood Friend Absolutely Will Not Lose
  • Season: 1
  • Episodes: 12
  • Genre: Romantic Comedy, Drama, School

A Romantic Comedy Where the Childhood Friend Absolutely Will Not Lose, also known as Osamake, focuses on Maru Sueharu who is heartbroken after his first love gets a boyfriend. His cheerful and cunning childhood friend, Kuroha Shida, swoops in to propose a revenge plot that launches them into a complicated love square, with an unexpected emphasis on comedy and complex rivalries. (49 words)

Watch this if you enjoy a fast-paced romantic comedy that intentionally subverts typical harem anime tropes for an unpredictable, fun ride. (20 words)

The Angel Next Door Spoils Me Rotten

The Angel Next Door Spoils Me Rotten - A heartwarming romance between the school idol Mahiru Shiina and her neighbor Amane Fujimiya.
The Angel Next Door Spoils Me Rotten
  • Season: 1
  • Episodes: 12
  • Genre: Romantic Comedy, Slice of Life, School

The Angel Next Door Spoils Me Rotten follows socially awkward Amane Fujimiya and his beautiful, angelic classmate and neighbor, Mahiru Shiina. Their bond forms unexpectedly when Mahiru decides to take care of Amane after he catches a cold, leading to a gentle, slow-burn slice of life romance built on daily interactions and heartwarming moments. (50 words)

This is a must-watch for fans of incredibly wholesome, domestic romantic comedy anime with a focus on deep character development. (19 words)

Oresuki: Are You the Only One Who Loves Me?

Oresuki: Are You the Only One Who Loves Me? - A high school boy's reverse-harem romantic comedy twist.
Oresuki: Are You the Only One Who Loves Me?
  • Season: 1
  • Episodes: 13
  • Genre: Romantic Comedy, Harem, School

Oresuki: Are You the Only One Who Loves Me?, also known as Ore wo Suki nano wa Omae dake ka yo, follows Amatsuyu Kisaragi, a seemingly charming boy who plots to get love confessions but discovers the girls only want to talk about his best friend. This romantic comedy flips the harem genre on its head for a fresh, hilarious take on high school love.

Watch this anime for a brilliant, self-aware deconstruction of rom-com tropes and unexpected laughs. It's a great choice for comedy fans.

The Girl I Like Forgot Her Glasses

The Girl I Like Forgot Her Glasses - A pure, wholesome romantic comedy about a very forgetful girl.
The Girl I Like Forgot Her Glasses
  • Season: 1
  • Episodes: 13
  • Genre: Romantic Comedy, School, Slice of Life

The Girl I Like Forgot Her Glasses, also known as Suki na Ko ga Megane wo Wasureta, is a pure and wholesome romantic comedy centered on Komura, a middle-school boy, and Mie, his forgetful classmate who constantly loses or forgets her glasses. Their awkward, cute interactions drive this sweet school life romance, focusing on the subtle growth of their feelings. It is a slow-burn favorite.

Its wholesome, gentle slice of life charm and pure relationship development make it a wonderfully calming and adorable watch for romance fans.

Masamune-kun's Revenge

Masamune-kun's Revenge - A high school boy's plan for romantic revenge on the girl who once rejected him.
Masamune-kun's Revenge
  • Season: 2
  • Episodes: 25
  • Genre: Romantic Comedy, School, Harem

Masamune-kun's Revenge, also known as Masamune-kun no Revenge, follows Masamune Makabe who was once a chubby boy mercilessly rejected by the beautiful but cruel Aki Adagaki. Now a handsome high schooler, Masamune returns with a meticulous plan: make Aki fall in love with him, then reject her to get his long-awaited **revenge**. This romantic comedy is full of twists and turns.

The intense psychological game and the appealing love triangle make this an engaging and surprisingly deep harem and romance series to follow.

The Quintessential Quintuplets

The Quintessential Quintuplets - A poor tutor's mission to help five beautiful, identical sisters graduate high school.
The Quintessential Quintuplets
  • Season: 2
  • Episodes: 24
  • Genre: Romantic Comedy, Harem, School

The Quintessential Quintuplets, also known as Go-Tōbun no Hanayome, centers on Fuutarou Uesugi, a financially struggling but academically gifted student hired to tutor the five beautiful but academically disastrous Nakano quintuplets. He must help the five distinct sisters pass their exams while one of them is destined to become his bride. This harem story is heartwarming and often hilarious.

It's a fantastic romantic comedy and mystery with excellent character development and a truly satisfying, emotional ending.

How to Raise a Boring Girlfriend

How to Raise a Boring Girlfriend - Tomoya Aki tries to produce a visual novel game with his schoolmates.
How to Raise a Boring Girlfriend
  • Season: 2
  • Episodes: 25
  • Genre: Romantic Comedy, Drama, School, Harem

How to Raise a Boring Girlfriend, also known as Saekano, centers on Tomoya Aki, an otaku determined to produce the best visual novel game ever after a fateful encounter. He recruits his brilliant but diverse schoolmates, including his supposedly "boring" inspiration, to form a creative circle, leading to a complex harem and hilarious drama. (50 words)

Watch this for a unique take on the harem genre blended with the passionate world of doujin game creation. (19 words)

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The Pet Girl of Sakurasou

The Pet Girl of Sakurasou - Sorata Kanda's life changes after he meets the artistic but helpless Mashiro Shiina.
The Pet Girl of Sakurasou
  • Season: 1
  • Episodes: 24
  • Genre: Romantic Comedy, Drama, School, Slice of Life

The Pet Girl of Sakurasou follows Sorata Kanda, who lives in the eccentric Sakurasou dorm and is tasked with looking after the genius artist Mashiro Shiina, who is incapable of basic self-care. Their shared life with other unique residents navigates themes of talent, hard work, unrequited love, and poignant coming-of-age drama. (50 words)

A beautifully animated slice of life show with compelling characters that perfectly balances comedy, romance, and serious emotional drama. (19 words)

Nisekoi: False Love

Nisekoi: False Love - Raku Ichijo and Chitoge Kirisaki pretend to date to prevent a gang war.
Nisekoi: False Love
  • Season: 2
  • Episodes: 32
  • Genre: Romantic Comedy, School, Harem

Nisekoi: False Love follows Raku Ichijo, heir to a Yakuza clan, and Chitoge Kirisaki, the daughter of a rival gang leader, who must enter a fake relationship to prevent an all-out war. Their hilariously chaotic student life is complicated by Raku's mysterious pendant, a childhood promise, and a growing harem of potential suitors. (50 words)

The definitive romantic comedy anime featuring an iconic love polygon, fantastic animation, and an abundance of slapstick humor. (19 words)

Oreimo: I Can't Go to My Sister!

Oreimo: I Can't Go to My Sister! - Kyousuke's complicated relationship with his otaku little sister, Kirino.
Oreimo: I Can't Go to My Sister!
  • Season: 2
  • Episodes: 29
  • Genre: Romantic Comedy, Drama, Slice of Life

Oreimo: I Can't Go to My Sister!, also known as Ore no Imōto ga Konna ni Kawaii Wake ga Nai, focuses on Kyousuke and his estranged little sister Kirino. He discovers her secret passion for otaku media, including eroge, forcing them to become closer to keep it hidden. The series is a dramatic, awkward, and surprisingly insightful look at family and hidden hobbies. (50 words)

This anime is a well-known, boundary-pushing slice of life comedy that tackles sibling relationships and otaku culture with bold drama. (19 words)

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Eromanga Sensei

Eromanga Sensei - Light novel author Masamune Izumi and his shut-in artist sister Sagiri.
Eromanga Sensei
  • Season: 1
  • Episodes: 14
  • Genre: Romantic Comedy, Drama, Harem

Eromanga Sensei follows high school light novel author Masamune Izumi, who discovers that his shut-in little sister, Sagiri, is secretly his mysterious, perverted illustrator, "Eromanga Sensei." Their relationship is the foundation for a quirky, incestuous romantic comedy that involves intense competition with rival authors. (49 words)

A vibrant, lighthearted harem comedy that delivers on cuteness and sibling-centered drama, making it a guilty-pleasure watch. (19 words)

Haganai: I Don't Have Many Friends

Haganai: I Don't Have Many Friends - A school club attempts to learn how to make friends.
Haganai: I Don't Have Many Friends
  • Season: 2
  • Episodes: 24
  • Genre: Romantic Comedy, School, Harem, Slice of Life

Haganai: I Don't Have Many Friends, also known as Boku wa Tomodachi ga Sukunai, features Hasegawa Kodaka, a transfer student who looks like a delinquent. He and the abrasive loner Yozora Mikazuki form the "Neighbors Club" to practice social skills and attempt to make friends, which hilariously backfires by attracting an eccentric harem of outcasts. (50 words)

An excellent school comedy with sharp wit that explores social awkwardness and friendship in a funny, yet occasionally heartfelt, way. (19 words)

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